Chemotherapy-refractory disease
WebThe use of techniques such as multiparametric flow cytometry and real-time quantitative PCR have improved detection of measurable residual disease, with numerous studies showing their prognostic value for relapse and overall survival (OS) [Citation 6, Citation 7].Although there are no validated criteria to consider a patient unfit for intensive … WebDec 5, 2015 · This approach achieved remission even in a patient with chemo-refractory disease, but more often failed when patients were not responsive to VP16/Dex. 21 Subsequently the HLH Study Group of the Histiocyte Society 22 launched the HLH-94 protocol, which combined etoposide induction with dexamethasone (DEX), and added …
Chemotherapy-refractory disease
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WebThe term “relapsed” refers to disease that reappears or grows again after a period of remission. The term “refractory” is used to describe when the lymphoma does not respond to treatment (meaning that the cancer cells continue to grow) or when the response to treatment does not last very long. For classical HL, most relapses typically ... WebBackground and Objectives Response to pre-transplant salvage chemotherapy remains the most important prognostic factor for outcome in refractory or relapsed Hodgkin’s lymphoma. Results of a new induction regimen are reported in terms of response rates, toxicity, and stem cell mobilization.Design and Methods Ninety-one patients with refractory or …
Webchemotherapy is tolerated less well in PNH patients than in leukemia patients, to avoid the risk of excessive bone marrow suppression, we used a low dose and a short course of treatment. PNH is a benign clonal disease, and normal clones and PNH clones coexist in PNH patients. The current treatment involves killing a considerable num- WebDec 3, 2015 · Twenty-one (84%) had primary refractory disease (n=13) or relapsed within 12 months after initial therapy (n=8). All had previous platinum-based salvage chemotherapy (ICE, 23; DHAP, 2). Ten …
WebMar 9, 2024 · A chemotherapy-free induction, consolidation, and maintenance strategy with venetoclax and blinatumomab in elderly patients with Ph-ALL is explored. Dear Editor, Clinically, the management of elderly patients with Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph-ALL) remains a challenge owing to their intolerance to … WebNov 5, 2024 · Relapsed and refractory sarcomas continue to have poor survival rates. The cancer stem cell (CSC) theory provides a tractable explanation for the observation that recurrences occur despite dramatic responses to upfront chemotherapy. Preclinical studies demonstrated that inhibition of the mechanistic target of rapamycin (mTOR) sensitizes …
WebOct 10, 2024 · Abstraction criteria were programmatic confirmation of refractory status defined as progressive disease as best response to any line of chemotherapy, stable …
WebMay 16, 2011 · In adult acute lymphoblastic leukemia (ALL), more than 80% of patients respond to induction chemotherapy with complete clinical remission, and yet up to 50% experience relapse with chemoresistant disease. 1 Thus, despite an impressive 40% to 50% overall survival rate (reached over the last 10 years), refractory relapsed leukemia … healthcheck in pythonWebPrevention. Chemorefractory is a term used to describe cancer that does not respond to chemotherapy (chemo) medications. 1. Cancer can be refractory to chemotherapy … gome hotel tiberiasWebMar 19, 2024 · Since refractory disease may be due to individual differences in pathophysiology, the use of tumor and other biomarkers will help predict or diagnose the occurrence of the tumor, its prognosis and ... healthcheck in podman containersWebHere, we report a patient with r/r BL who failed to achieve complete remission (CR) and progressed rapidly after multiple protocol chemotherapy. The patient achieved CR with CAR19 and CAR22 T-cell cocktail therapy and obtained long-term disease-free survival after autologous hematopoietic stem cells (ASCT) and subsequential CAR19 and CAR22 … gomelo specials 2022WebApr 5, 2024 · The goal of therapy in relapsed and/or refractory (R/R) ALL is to induce a subsequent remission and then to consolidate that complete response (CR) with an allogeneic hematopoietic cell transplant (allo-HCT) on the basis of a significant survival benefit seen with an allo-HCT. 5 To achieve a CR after relapse and proceed with allo … health checking a reptileWebMar 7, 2024 · Chemotherapy nephrotoxicity and dose modification in patients with kidney impairment: Molecularly targeted agents and immunotherapies; Clinical features and … health check in oregonWebReduced-intensity—a form of allogeneic transplantation in which patients receive lower doses of chemotherapy drugs and/or radiation therapy in preparation for the transplant. Autologous stem cell transplantation remains a key component of the standard medical care for patients with aggressive forms of non-Hodgkin lymphoma (NHL). gomel meat processing plant